Effects of Nigella sativa oil extract on inflammatory cytokine response and oxidative stress status in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled clinical trial

نویسندگان

  • Alireza Khabbazi Department of Internal Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  • Hossein Hosseini Department of Agriculture, Barij Essence Pharmaceutical Company, Kashan, Iran
  • Mohammad Alizadeh Department of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran
  • Sorayya Kheirouri Department of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran
  • Vahid Hadi Department of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran
چکیده مقاله:

Objectives: Nigella sativa is a medicinal plant that has long been used in traditional medicine for treating various conditions. Numerous animal studies provided evidences that the seed may elicit a broad anti-inflammatory/anti-oxidant activity. The aim of the present clinical trial was to evaluate anti-inflammatory and antioxidant properties of Nigella sativa oil in patients with rheumatoid arthritis (RA). Materials and Methods: Forty-two patients with RA were assigned into two groups in this randomized, double blind, placebo-controlled clinical trial. Subjects in intervention group received two capsules, 500 mg each, of Nigella sativa oil, each day for 8 weeks. The other group consumed two capsules as placebo per day for the same period of time. Serum TNF-α, IL-10, and whole blood levels of oxidative stress parameters were measured at baseline and end of the trial. Results: The serum level of IL-10 was increased in the Nigella sativa group (p

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منابع مشابه

effects of nigella sativa oil extract on inflammatory cytokine response and oxidative stress status in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled clinical trial

objectives: nigella sativa is a medicinal plant that has long been used in traditional medicine for treating various conditions. numerous animal studies provided evidences that the seed may elicit a broad anti-inflammatory/anti-oxidant activity. the aim of the present clinical trial was to evaluate anti-inflammatory and antioxidant properties of nigella sativa oil in patients with rheumatoid ar...

متن کامل

Effects of Nigella sativa oil extract on inflammatory cytokine response and oxidative stress status in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled clinical trial.

OBJECTIVE Nigella sativa is a medicinal plant that has long been used in traditional medicine for treating various conditions. Numerous animal studies provided evidences that the seed may elicit a broad anti-inflammatory/anti-oxidant activity. The aim of the present clinical trial was to evaluate anti-inflammatory and antioxidant properties of Nigella sativa oil in patients with rheumatoid arth...

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Effects of Nigella sativa L. Seed Oil in Type II Diabetic Patients: a Randomized, Double-Blind, Placebo - Controlled Clinical Trial

Background: Nigella sativa (N. sativa) seeds are used to treat diabetes mellitus in traditional medicine. Moreover, N. sativa oil has reduced the fasting blood glucose level in non-diabetic volunteers. Objective: The present study was undertaken to explore the possible anti-hyperglycemic effect of N. sativa oil in type II diabetic patients. Methods: A randomized clinical trial was conducted ...

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Effect of Nigella sativa oil extracts on inflammatory and oxidative stress markers in Behcet’s disease: A randomized, double-blind, placebo-controlled clinical trial

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effects of nigella sativa l. seed oil in type ii diabetic patients: a randomized, double-blind, placebo - controlled clinical trial

background: nigella sativa (n. sativa) seeds are used to treat diabetes mellitus in traditional medicine. moreover, n. sativa oil has reduced the fasting blood glucose level in non-diabetic volunteers. objective: the present study was undertaken to explore the possible anti-hyperglycemic effect of n. sativa oil in type ii diabetic patients. methods: a randomized clinical trial was conducted in ...

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Efficacy of Nigella sativa seeds oil in patients with Behcet’s disease: a double-blind randomized controlled trial

Objective: Nigella sativa (NS) is a herbal medicine with anti-inflammatory and anti-oxidant functions. This study was designed to evaluate the effect of oral administration of NS seeds oil on the treatment of Behcet’s disease (BD). Materials and methods:In this double-blind randomized controlled study, 130 patients with BD were screened and 71 patients with BD were randomly allocated to the tre...

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عنوان ژورنال

دوره 6  شماره 1

صفحات  34- 43

تاریخ انتشار 2016-01-01

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